Pinetree Therapeuticsでは最高技術責任者(CTO)を募集しています。抗体工学およびタンパク質分解プラットフォーム技術を統括する、15年以上の経験を持つ専門家を求めています。多重特異性抗体設計とCMC戦略の策定が主要業務です。抗体治療薬開発の全工程をリードし、技術組織を成長させる能力が必要です。マサチューセッツ州ケンブリッジで勤務し、革新的な新薬開発を主導するリーダーをお待ちしています。
Recruiting
Chief Technology Officer
Pinetree Therapeutics
26.07.28
Chief Technology Officer (CTO)
Antibody Engineering, Platform Technology & CMC Location: Cambridge, MA (on-site)
Reports to: Chief Executive Officer (CEO)
Role Type: Full-time, on-site executive
Start Date: Immediate
About Pinetree Therapeutics
Pinetree Therapeutics is a rapidly growing biotechnology company developing next- generation multispecific antibody therapies for targeted protein degradation in oncology and immune modulation. Our proprietary AbReptor™ platform is a first-in-class extracellular targeted protein degradation (eTPD) technology that uses bispecific and multispecific antibodies to redirect disease-driving cell-surface and extracellular proteins to lysosomal degradation, going beyond inhibition to remove the disease driver itself, overcoming drug resistance and disease recurrence.
Our lead program, EGFR AbReptor™ (PTX-299), is licensed to AstraZeneca and advancing toward first-in-human studies, with a growing wholly-owned pipeline spanning c-MET, FGFR2, and additional targets, plus platform extensions into degrader- antibody and antibody-drug conjugates (DuoDACtyl™ / dADC) and inflammation &
immunology. With research operations in Cambridge, MA and a clinical and preclinical site in South Korea, we are a lean, hands-on, science-driven organization translating innovative discovery concepts into first-in-class clinical candidates for patients with “hard-to-treat” cancers and immune disorders.
Position Summary
We are seeking a seasoned biotech leader to serve as Chief Technology Officer (CTO), the senior-most technical authority for antibody engineering, the AbReptor™ platform, and CMC. Reporting to the CEO, the CTO will own the scientific and technical direction of the platform and all antibody engineering and molecule development from discovery through candidate nomination and IND-enabling readiness, leading Pinetree’s established team of antibody engineering Directors and Principal Scientists while working alongside the company’s scientific, clinical, and business leadership.
The ideal candidate is an accomplished antibody engineer and drug developer with deep, hands-on expertise in multispecific antibody and antibody-fusion construct design, and a proven record of advancing biologics from concept into the clinic. This is an active, hands-on technical leadership role: you will be the company’s definitive decision- maker on antibody design and engineering, drive the hardest molecular design, developability, and CMC decisions, and expand the platform into new modalities. The successful candidate will be authoritative and self-sufficient enough to independently own the antibody engineering function and set molecular design direction across the portfolio, while elevating an already-strong engineering team.
Key Responsibilities
1. Platform & Technology Strategy
ensuring Pinetree sustains its differentiation and first-in-class position in antibody-based protein degradation.
generation multispecific degraders with tumor-microenvironment modulation, degrader- antibody conjugates (DAC / DuoDACtyl™), and degrading ADCs (dADC).
contribute to target selection, program prioritization, timelines, and go/no-go decisions.
2. Antibody & Protein Engineering Leadership
design strategy and the final technical decisions across the multispecific degrader portfolio.
construct design, including format selection, epitope and affinity tuning, valency, and geometry optimization, to achieve potent, selective degradation with a desirable safety profile.
optimization, embedding developability, manufacturability, and safety considerations early (“developability by design”).
characterization problems, guiding structure-activity analysis and troubleshooting across programs.
3. Discovery-to-Candidate Development
and candidate nomination, ensuring molecules are designed to meet target product profiles and clinical requirements.
biology, translational, and DMPK/toxicology functions to support robust candidate selection and IND-enabling readiness.
development and early clinical supply.
4. CMC, Developability Technical Operations
line and process development, formulation, analytics, and comparability, partnering closely with Pinetree’s experienced senior CMC leadership.
manufacturability, stability, and aggregation early in the engineering process.
high-quality material and data on timelines that support program milestones, with day- to-day CDMO management led by the CMC function.
5. Intellectual Property & Platform Innovation
around the AbReptor™ platform, novel formats, and engineering approaches.
operate assessments as the platform and pipeline expand.
conjugate landscapes to guide differentiation and defensibility.
6. Organizational & Cross-Functional Leadership
technical development organization, an established team of Directors and Principal Scientists, fostering a culture of scientific rigor, speed, ownership, and collaboration.
technical strategy with corporate objectives.
representing Pinetree’s platform and technical strategy to external stakeholders.
in alignment with strategic priorities.
Qualifications
Required
chemical/biomolecular engineering, or a related discipline (or equivalent experience).
engineering, and development, including senior leadership roles (CTO, CSO, SVP/VP of Antibody Engineering, Protein Sciences, or Biologics Development), with the depth and standing to serve as an organization’s top antibody engineering authority.
designing and optimizing multispecific (bispecific/trispecific) antibodies and antibody- fusion constructs.
optimization, candidate nomination, and IND-enabling development into the clinic.
including cell line/process development, formulation, analytics, and manufacturability, with the ability to provide executive oversight of CMC and technical development.
Principal Scientists) and to operate independently and decisively as the senior technical authority in a lean, fast-paced environment.
Preferred
including multispecific degraders, antibody-fusion constructs, ADCs, or degrader- antibody conjugates.
invention disclosures) at a biotech.
with pharma partners.
Experience across both oncology and immunology/inflammation (I&I) indications.
History of scaling technical organizations and capabilities from early-stage through
clinical development.
Compensation & Benefits
We offer a highly competitive compensation package, including equity participation that reflects the strategic importance of this executive role and the opportunity to share in the company’s long-term growth and success. Pinetree offers comprehensive benefits, including medical and dental insurance, paid time off, and a 401(k) with a company match.
Why Join Us
This is a rare opportunity to be the technical and scientific engine of a validated, first-in- class protein degradation platform, leading antibody engineering and platform innovation while providing executive oversight of CMC. As CTO, you will have the autonomy and resources to set molecular design direction, expand the platform into new modalities, and lead an accomplished engineering team advancing a pipeline with true breakthrough potential for patients with drug-resistant and refractory disease. If you are a hands-on antibody engineer and builder energized by inventing and advancing transformative medicines in a mission-driven, fast-moving environment, we would love to meet you.
Recruitment & Staffing Agencies
Pinetree does not accept unsolicited resumes from any source other than candidates.
Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree.
Pinetree Therapeutics is an equal-opportunity employer committed to a collaborative, multidisciplinary, and transformative company culture.
